Seungyup Lee, PhD

Assistant Professor
Department of Medicine
School of Medicine
Assistant Professor
Biomedical Engineering
Case School of Engineering

Research Information

Research Interests

I have over 15 years of experience in the fields of cardiovascular engineering, cardiac electrophysiology, and medical devices. I have been interested in the mechanism of atrial fibrillation and signal processing. I have researched two canine models (sterile pericarditis and vagal nerve stimulation atrial fibrillation) and human persistent or postoperative atrial fibrillation to understand the mechanism of atrial fibrillation. I have developed, improved, and applied several signal processing analysis algorithms in both time and frequency domains to characterize atrial electrograms of atrial fibrillation during real-time data acquisition. I have applied these analysis algorithms to clinical studies. Using high density mapping with these algorithms, we can understand the mechanism of atrial fibrillation and apply real-time analysis algorithms to improve surgical or catheter ablation therapies. More recently, I have partnered with a manufacturing company for developing a smart mapping catheter (catheter + analysis algorithm).

Publications

  • Lee S., Khrestian CM, Laurita D, Juzbasich D, Wallick D, Waldo AL. Pacing and Clinical Electrophysiology 2023; 1 - 7.  
  • Lee S., Khrestian CM, Sahadevan J, Waldo AL. Journal of Clinical Medicine. 2022;11(19), 5807.
  • Lee S, Vitebskiy S, Goldstein RN, Khrestian CM and Waldo AL. Heart Rhythm O2. 2022;3:91-96.   
  • Schotten U., Lee S., Zeemering S., Waldo AL. Europace, 2021; 23(Supplement_2): ii9-ii13.
  • Lee S., Khrestian CM., Sahadevan J., Markowitz A., Waldo AL. JACC Clin Electrophysiol. 2021;7:909-919.
  • Lee S, Khrestian CM, Sahadevan J, Waldo AL. Heart Rhythm 2020. PMID: 32585192
  • Lee S., Khrestian A., Waldo AL., Khrestian CM., Markowitz A., Sahadevan J. Journal of the American Heart Association. 2019;8:e011401 PMCID: PMC6585332
  • Lee S., Sahadevan J., Khrestian C., Markowitz A., Waldo A.L. Journal of American Heart Association 2017;6(3):e005274. PMCID:PMC5524032
  • Lee S., Sahadevan J., Khrestian C., Cakulev I., Markowitz A., Waldo A.L. Circulation 2015;132:2108-2117. PMCID: PMC4666790
  • Sadrpour S.A., Srinivasan D., Bhimani A.A., Lee S., Ryu K., Cakulev I., Khrestian C.M., Markowitz A., Waldo A.L., Sahadevan J. Europace 2015;17(12):1834-9. PMID: 25911349
  • Sadrpour S.A., Serhal M., Khrestian C., Lee S., Fields T., Dittrich H., Waldo A.L. J Cardiovasc Pharmacol 2015;65:494-9.
  •  Bhimani A.A., Yasuda T., Sadrpour S.A., Khrestian C.M., Lee S., Zeng D., Belardinelli L., Waldo A.L. Heart Rhythm, 2014;11:1592-99.        
  • Lee S, Sahadevan J, Khrestian C, Durand D, Waldo A. Journal of Cardiovascular Electrophysiology 2013;24:328-335.  PMID: 23210508
  • Lee S, Ryu K, Waldo A, Khrestian C, Durand D, Sahadevan J. Journal of Cardiovascular Electrophysiology. 2013;24:199-206. PMID: 23140386

Education

Doctor of Philosophy
Biomedical Engineering
ºÚÁϳԹÏÍø
2013
Masters of Science
Biomedical Engineering
ºÚÁϳԹÏÍø
2008
Bachelors of Science
Electrical Engineering and Computer Science
Kyungpook National University
2005

Residencies, Internships and Fellowships

Cardiology
ºÚÁϳԹÏÍø/University Hospitals Cleveland Medical Center
2016